AP-1A and AP-3A Lysosomal Sorting Functions
نویسندگان
چکیده
منابع مشابه
The AP-1A and AP-1B clathrin adaptor complexes define biochemically and functionally distinct membrane domains
Most epithelial cells contain two AP-1 clathrin adaptor complexes. AP-1A is ubiquitously expressed and involved in transport between the TGN and endosomes. AP-1B is expressed only in epithelia and mediates the polarized targeting of membrane proteins to the basolateral surface. Both AP-1 complexes are heterotetramers and differ only in their 50-kD mu1A or mu1B subunits. Here, we show that AP-1A...
متن کاملAP-3 regulates PAR1 ubiquitin-independent MVB/lysosomal sorting via an ALIX-mediated pathway
The sorting of signaling receptors within the endocytic system is important for appropriate cellular responses. After activation, receptors are trafficked to early endosomes and either recycled or sorted to lysosomes and degraded. Most receptors trafficked to lysosomes are modified with ubiquitin and recruited into an endosomal subdomain enriched in hepatocyte growth factor-regulated tyrosine k...
متن کاملNeuronal and non-neuronal functions of the AP-3 sorting machinery.
Vesicles selectively exchange lipids, membrane proteins and luminal contents between organelles along the exocytic and endocytic routes. The repertoire of membrane proteins present in these vesicles is crucial for their targeting and function. Vesicle composition is determined at the time of their biogenesis by cytosolic coats. The heterotetrameric protein adaptor protein complex 3 (AP-3), a co...
متن کاملAcute Pancreatitis (AP) and Dietary Habbits
Inflammation of pancreatic parenchyma is said to be pancreatitis. It can be acute, presenting as emergency with short history or chronic as a continuation of acute with a long history. Autodigestion is responsible for pancreatitis on background of premature activation of pancreatic enzymes within the pancreas. Acute Pancreatitis is acute inflammation of the pancrease which can be mild to modera...
متن کاملMATRIX Ap WEIGHTS VIA MAXIMAL FUNCTIONS
Weighted Norm theory forms a basic component of the study of singular integrals. Here one attempts to characterize those measure spaces over which a broad class of singular integral operators remain bounded. For the case of singular integral operators on C-valued functions in Euclidean space, the answer is given by the Hunt-Muckenhoupt-Wheeden theorem [10]. It states that the necessary and suff...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Traffic
سال: 2002
ISSN: 1398-9219
DOI: 10.1034/j.1600-0854.2002.31007.x